The APC Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to APC, and APC regulator of WNT signaling pathway. This antibody recognizes Human, Mouse, and Rat antigen. The APC Polyclonal Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Immunohistochemistry.
Description
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product